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BackTable / Innovation / Podcast / Episode #45

Supraphysiological Wound Care: From Hot Water Bottle to Plexaa

with Dr. Saahil Mehta

In this episode, Dr. Diana Velazquez-Pimentel interviews plastic surgeon and Plexaa founder Dr. Saahil Mehta. They discuss the novel concept of preconditioning the skin before reconstructive breast surgery and Plexaa’s product solution for reducing wound healing complications.

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Supraphysiological Wound Care: From Hot Water Bottle to Plexaa with Dr. Saahil Mehta on the BackTable Innovation Podcast)
Ep 45 Supraphysiological Wound Care: From Hot Water Bottle to Plexaa with Dr. Saahil Mehta
00:00 / 01:04

BackTable, LLC (Producer). (2023, February 10). Ep. 45 – Supraphysiological Wound Care: From Hot Water Bottle to Plexaa [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Saahil Mehta discusses Supraphysiological Wound Care: From Hot Water Bottle to Plexaa on the BackTable 45 Podcast

Dr. Saahil Mehta

Dr. Saahil Mehta is a plastic surgeon and founder of Plexaa.

Dr. Diana Velazquez-Pimentel discusses Supraphysiological Wound Care: From Hot Water Bottle to Plexaa on the BackTable 45 Podcast

Dr. Diana Velazquez-Pimentel

Dr. Diana Velazquez-Pimentel is practicing physician and an NHS Clinical Entrepreneur in London.

Show Notes

Dr. Mehta first started exploring the topic of preconditioning the body for healing when he learned about skin-sparing mastectomy. He realized that while this procedure provided great benefit for reconstruction outcomes, it left behind thin, poorly perfused skin that was vulnerable to necrosis. Dr. Mehta started a clinical research project over heat stress and the subsequent chaperone protein and endogenous carbon monoxide release that allows for vasodilation and improved perfusion. His early studies involved mouse models and human patients who used hot water bottles over their skin on the day before surgery. The promising data led Dr. Mehta to apply for and win an NIHR grant to run a full clinical trial with heated water bottles. He found that preconditioning and applying supraphysiological heat stress to the skin prior to operation resulted in reductions in rates of skin necrosis, re-operation, and need for outpatient follow up.

Today, Plexaa is a bra insert that can be heated to an exact temperature using a phone app. The technology is made possible by a principal circuit board that ensures a safe and accurate heat delivery to breast cancer patients who may have altered sensation to skin sensation from prior radiation therapy and chemotherapy. Plexaa has partnered with institutions and is planning to help doctors and nurses incorporate the product into their pre-operative planning and send Plexaa directly to patients’ homes. In the future, Plexaa aims to bring its technology to other surgical specialties such as orthopedics and ENT.

Resources

Preconditioning preHEAT Clinical Trial:
https://pubmed.ncbi.nlm.nih.gov/30656059/

Future Surgery Conference:
https://www.futuresurgeryshow.com/

Plexaa:
https://plexaa.com/

Email:
saahil@plexaa.com

Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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