Episode # 235 • 05 Aug 2025
Biologics for Chronic Rhinosinusitis with Nasal Polyps
How do we integrate biologics into the existing stepwise treatment model for chronic rhinosinusitis with nasal polyps (CRSwNP)? In this episode, Dr. Reena Mehta, an allergist from Uptown Allergy and Asthma in New Orleans, discusses the use of biologics for treating chronic rhinosinusitis with nasal polyps.
Timestamps
00:00 - Introduction
02:27 - Understanding Chronic Rhinosinusitis with Nasal Polyps & Presentation
05:22 - Workup and Management of Nasal Polyps
07:31 - Treatment Options: Steroids and Biologics
15:28 - Tezepelumab: A New Tool in the Toolkit
25:03 - Side Effects and Safety of Biologics
28:59 - Insurance and Approval Challenges
36:14 - Long-Term Safety and Efficacy
38:47 - Pediatric Considerations and Future Directions
41:37 - Collaboration Between ENT and Allergy Specialists
45:07 - Conclusion and Final Thoughts
Resources
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More about this episode
Dr. Mehta elaborates on the common presentations of patients, the role of biologics such as dupilumab and tezepelumab, and the nuances of patient management post-sinus surgery. Dr. Mehta also covers the workup process, the significance of patient comorbidities like asthma and allergies, and the future perspectives on biologic treatments. Practical aspects of biologic therapy, including insurance hurdles, patient compliance, and the effectiveness of various biologics are thoroughly examined.
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