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BackTable / Tumor Board / Podcast / Episode #28
How Biomarkers Enhance Precision Medicine in Non-Muscle Invasive Bladder Cancer
with Dr. Katie Murray and Dr. Sarah Psutka
As new genetic and AI-powered tools emerge for bladder cancer screening, are we getting closer to reducing the need for invasive cystoscopies? In part five of the 2025 BackTable NMIBC Creator Weekend™ series, host Dr. Vignesh Packiam engages in an insightful discussion with Dr. Sarah Psutka from the University of Washington and Dr. Katie Murray from NYU about the complexities and potential benefits of using biomarkers in non-muscle invasive bladder cancer (NMIBC).
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BackTable, LLC (Producer). (2025, October 7). Ep. 28 – How Biomarkers Enhance Precision Medicine in Non-Muscle Invasive Bladder Cancer [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Synopsis
The conversation covers the current challenges of interpreting positive biomarkers without clinical correlates, the gold standard of biopsies, and the potential of various biomarkers such as urine cytology, FISH, and newer genomic tests like the Decipher Bladder Genomic Classifier. They also touch upon the role of AI in pathology, the cost implications of biomarkers, and how these tools might influence future clinical practices and patient decisions. The episode emphasizes the need for precision medicine, careful patient counseling, and the impact of false positives and negatives on both patients and healthcare providers.
Timestamps
00:00 - Introduction
05:25 - Challenges with Current Biomarkers
08:10 - New Biomarkers and Genomic Classifiers
21:10 - AI and Pathology in Bladder Cancer
35:13 - Screening and Future Directions
41:20 - Challenges and Future Directions in Bladder Cancer Surveillance
57:51 - Conclusion
Resources
DaBlaCa-15 Trial
https://pubmed.ncbi.nlm.nih.gov/40280776/
Sam Chang CHAI Study
https://pubmed.ncbi.nlm.nih.gov/40514253/
The Materials available on BackTable are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
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