Episode # 21 • 20 Jan 2026
Current HFpEF Treatments: Clinical Pearls & Progress
If your New Year’s resolution involves learning more about current practice guidelines and emerging research on Heart Failure with Preserved Ejection Fraction (HFpEF), you’re in the right place! In this episode of the BackTable Cardiology Podcast, host Dr. Hady Lichaa welcomes heart failure specialist Dr. Jessica Huston to provide a practical update on managing heart failure with preserved ejection fraction (HFpEF).
Timestamps
00:00 - Introduction
02:20 - Understanding HFpEF
05:23 - Phenotypes and Treatment Approaches
06:29 - Metabolic Syndrome and HFpEF
09:17 - Emerging Treatments and Clinical Trials
11:36 - Medication Strategies and Challenges
24:51 - Diuretics and Their Limitations
31:35 - Advanced Diuretic Strategies
35:37 - Hemodynamic Measurements and Their Implications
40:02 - Coronary Disease and HFpEF
42:52 - Future Directions in Heart Failure Treatment
45:45 - Device Therapies and Patient Management
49:39 - Concluding Thoughts and Future Prospects
Resources
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More about this episode
Dr. Huston and Dr. Lichaa discuss the complexity of diagnosing HFpEF, differences between HFpEF and diastolic heart failure, phenotypes within HFpEF, and treatment strategies, including the use of aldosterone blockers, SGLT-2 inhibitors, and GLP-1 agonists. Dr. Huston emphasizes the importance of phenotyping patients for accurate diagnosis and treatment, and discusses the potential of future therapies and devices. Their conversation also covers the role of inflammation, metabolic syndrome, and the challenges faced in managing fluid balance and hypertension in HFpEF patients.
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