.png){kind=small}
.png){kind=small}
BackTable / Cardiology / Podcast / Episode #22
The Role of Cangrelor in Modern Interventional Cardiology: Practice, Guidelines, & Data Review
with Dr. Roxana Mehran
Fast acting and reversible: IV cangrelor offers rapid on, rapid off P2Y12 platelet inhibition that sidesteps oral absorption delays. In this episode of the BackTable Cardiology Podcast, host Dr. Sameh Sayfo welcomes renowned interventional cardiologist Dr. Roxana Mehran, incoming President elect of the American College of Cardiology (ACC), to discuss the emerging role of cangrelor and its implications on current cardiology practice.
This podcast is supported by an educational grant from Cheisi.
BackTable, LLC (Producer). (2026, January 27). Ep. 22 – The Role of Cangrelor in Modern Interventional Cardiology: Practice, Guidelines, & Data Review [Audio podcast]. Retrieved from https://www.backtable.com
Stay Up To Date
Follow:
Subscribe:
Sign Up:
Podcast Contributors
Synopsis
Dr. Mehran and Dr. Sayfo cover the history and outcomes of the CHAMPION PHOENIX trial, cangrelor’s adoption and underutilization, and the nuances of transitioning high acuity patients between IV and PO antiplatelet therapies. Dr. Mehran also addresses the role of gender in cardiovascular health and the importance of inclusive representation in clinical studies. The episode concludes with Dr. Mehran sharing her initiatives to support women and minorities in cardiology, including her work as co-founder of Women As One.
Timestamps
00:00 - Introduction to the BackTable Podcast
01:57 - Understanding Cangrelor and Its Impact
02:18 - CHAMPION PHOENIX Study Insights
07:02 - Challenges and Misconceptions of Cangrelor in Cardiogenic Shock and STEMI
14:41 - Antiplatelet Bridging to Surgery and Gender Differences in Treatment
17:39 - The SMILE Study and Real-World Applications
20:49 - Advancing Women in Cardiology
29:22 - Future of Interventional Cardiology
32:53 - Holistic Cardiac and Vascular Health
36:01 - Conclusion and Final Thoughts
Resources
Dr. Roxana Mehran:
https://profiles.mountsinai.org/roxana-mehran
Dr. Sameh Sayfo:
https://www.bswhealth.com/physician/sameh-sayfo
Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events (CHAMPION PHOENIX Trial):
https://www.nejm.org/doi/full/10.1056/NEJMoa1300815
Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition – CHAMPION Platform Clinical Trial
https://www.clinicaltrials.gov/study/NCT00385138
Intravenous Platelet Blockade with Cangrelor during PCI (CHAMPION PCI):
https://www.nejm.org/doi/full/10.1056/NEJMoa0908629
Meta-Analysis of the Role of Cangrelor for Patients Undergoing Percutaneous Coronary Intervention
https://www.sciencedirect.com/science/article/abs/pii/S0002914919300426
Timing, indications and transition patterns associated with cangrelor use in patients undergoing PCI
https://pubmed.ncbi.nlm.nih.gov/40813532/
Women As One
https://womenasone.org/about/
The Materials available on BackTable are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
Up Next
Articles
Topics
