Podcast #22 · 27 Jan 2026
The Role of Cangrelor in Modern Interventional Cardiology: Practice, Guidelines & Data Review
- Percutaneous Coronary Intervention (PCI)
- Interventional Cardiology (IC)
- ST-Elevation Myocardial Infarction (STEMI)
- Cardiogenic Shock
- Dual Antiplatelet Therapy (DAPT)
- Women in Medicine
- Acute Coronary Syndrome (ACS)
Fast acting and reversible: IV cangrelor offers rapid on, rapid off P2Y12 platelet inhibition that sidesteps oral absorption delays. In this episode of the BackTable Cardiology Podcast, host Dr. Sameh Sayfo welcomes renowned interventional cardiologist Dr. Roxana Mehran, incoming President elect of the American College of Cardiology (ACC), to discuss the emerging role of cangrelor and its implications on current cardiology practice.
This podcast is supported by an educational grant from Chiesi.
Timestamps
Resources
- Dr. Roxana Mehran
- Dr. Sameh Sayfo
- Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events (CHAMPION PHOENIX Trial)
- Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition – CHAMPION Platform Clinical Trial
- Intravenous Platelet Blockade with Cangrelor during PCI (CHAMPION PCI)
- Meta-Analysis of the Role of Cangrelor for Patients Undergoing Percutaneous Coronary Intervention
- Timing, indications and transition patterns associated with cangrelor use in patients undergoing PCI
- Women As One
More about this episode
Dr. Mehran and Dr. Sayfo cover the history and outcomes of the CHAMPION PHOENIX trial, cangrelor’s adoption and underutilization, and the nuances of transitioning high acuity patients between IV and PO antiplatelet therapies. Dr. Mehran also addresses the role of gender in cardiovascular health and the importance of inclusive representation in clinical studies. The episode concludes with Dr. Mehran sharing her initiatives to support women and minorities in cardiology, including her work as co-founder of Women As One.