Episode # 22 • 27 Jan 2026
The Role of Cangrelor in Modern Interventional Cardiology: Practice, Guidelines & Data Review
Fast acting and reversible: IV cangrelor offers rapid on, rapid off P2Y12 platelet inhibition that sidesteps oral absorption delays. In this episode of the BackTable Cardiology Podcast, host Dr. Sameh Sayfo welcomes renowned interventional cardiologist Dr. Roxana Mehran, incoming President elect of the American College of Cardiology (ACC), to discuss the emerging role of cangrelor and its implications on current cardiology practice.
This podcast is supported by an educational grant from Cheisi.
Timestamps
00:00 - Introduction to the BackTable Podcast
01:57 - Understanding Cangrelor and Its Impact
02:18 - CHAMPION PHOENIX Study Insights
07:02 - Challenges and Misconceptions of Cangrelor in Cardiogenic Shock and STEMI
14:41 - Antiplatelet Bridging to Surgery and Gender Differences in Treatment
17:39 - The SMILE Study and Real-World Applications
20:49 - Advancing Women in Cardiology
29:22 - Future of Interventional Cardiology
32:53 - Holistic Cardiac and Vascular Health
36:01 - Conclusion and Final Thoughts
Resources
- Dr. Roxana Mehran
- Dr. Sameh Sayfo
- Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events (CHAMPION PHOENIX Trial)
- Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition – CHAMPION Platform Clinical Trial
- Intravenous Platelet Blockade with Cangrelor during PCI (CHAMPION PCI)
- Meta-Analysis of the Role of Cangrelor for Patients Undergoing Percutaneous Coronary Intervention
- Timing, indications and transition patterns associated with cangrelor use in patients undergoing PCI
- Women As One
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More about this episode
Dr. Mehran and Dr. Sayfo cover the history and outcomes of the CHAMPION PHOENIX trial, cangrelor’s adoption and underutilization, and the nuances of transitioning high acuity patients between IV and PO antiplatelet therapies. Dr. Mehran also addresses the role of gender in cardiovascular health and the importance of inclusive representation in clinical studies. The episode concludes with Dr. Mehran sharing her initiatives to support women and minorities in cardiology, including her work as co-founder of Women As One.
The Materials available on BackTable are provided for informational and educational purposes only and are not a substitute for the independent professional judgment of a qualified healthcare professional in diagnosing or treating patients. Any opinions, statements, or views expressed are those of the individual contributors and do not necessarily reflect those of the publisher, platform, or any affiliated organization.