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BackTable / Cardiology / Podcast / Episode #26
Renal Denervation: Innovations in Hypertension Management
with Dr. Eric Secemsky, Dr. Sameh Sayfo
John Doe is a 45 year-old male with a past medical history of hypertension, on high doses of amlodipine, metoprolol and lisinopril presenting to his cardiologist with a blood pressure of 165/86. He asks, “If the medications are not controlling my blood pressure, what are my options?” In this episode of the BackTable Cardiology Podcast, Dr. Sameh Sayfo sits down with Dr. Eric Secemsky, an internationally recognized interventional cardiologist and vascular medicine specialist to discuss renal denervation, a minimally invasive procedure that lowers blood pressure by disrupting overactive renal sympathetic nerves.
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BackTable, LLC (Producer). (2026, February 24). Ep. 26 – Renal Denervation: Innovations in Hypertension Management [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Synopsis
From its proof of concept to the clinical trials that have shaped the current landscape, Drs. Sayfo and Secemsky dive into the intricacies of renal denervation. They explore the technical aspects of catheter-based denervation devices like Medtronic's Spyral catheter and Recor's Paradise device, discussing their procedures, safety features, and troubleshooting tips. The conversation also covers the significance of building advanced hypertension centers, the latest in renal denervation innovations, and the creation of a national registry to track procedural outcomes and enhance patient care.
Timestamps
00:00 - Introduction
02:52 - Guidelines Update: Why Renal Denervation Earned a Class 2B Recommendation
07:31 - Clinical Trials: What Went Wrong, What We Learned, and How Devices Improved
15:08 - Medtronic Symplicity Spyral
22:17 - ReCor Paradise
27:30 - Covering the Main Renal Artery: Anatomic Variants and Proximal Treatment Strategy
33:15 - Beyond Kidneys: Multi-Organ Denervation and Metabolic Effects
40:27 - Why Institutions Should Build Hypertension Centers
Resources
Dr. Sameh Sayfo’s Provider Profile
https://www.bswhealth.com/physician/sameh-sayf
Dr. Eric Secemsky’s Provider Profile
https://findadoc.bidmc.org/details/3519
A Controlled Trial of Renal Denervation for Resistant Hypertension
https://www.nejm.org/doi/full/10.1056/NEJMoa1402670
Medtronic Symplicity Spyral™ Renal Denervation System
https://www.medtronic.com/en-us/healthcare-professionals/products/surgical-energy/ablation/radiofrequency-ablation/systems/symplicity-spyral-renal-denervation-system.html
SPYRAL GEMINI Pilot Study
https://clinicaltrials.gov/study/NCT06907147
Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities (NECTAR IV) Trial
https://clinicaltrials.gov/study/NCT05369065
The Materials available on BackTable are provided for informational and educational purposes only and are not a substitute for the independent professional judgment of a qualified healthcare professional in diagnosing or treating patients. Any opinions, statements, or views expressed are those of the individual contributors and do not necessarily reflect those of the publisher, platform, or any affiliated organization.
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