Dr. Theofanie Mela
Cardiac Electrophysiologist & Cardiologist
1 Podcast on BackTable
Dr. Theofanie Mela is a cardiac electrophysiologist and cardiologist at Mass General Hospital in Boston, Massachusetts.
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Episode # 450 • 25 May 2026
Journal Club: The I-CLASS Registry
Join CardioNerds EP Council Chair Dr. Naima Maqsood and Episode Lead Dr. Sukriti Banthiya as they discuss the results of the International Collaborative LBBAP Study (I-CLAS) with expert faculty Dr. Theofanie Mela and Dr. Pugazhendhi Vijayraman. Audio editing by CardioNerds academy intern, Grace Qiu.
The International Collaborative LBBAP Study (I-CLAS) evaluated clinical outcomes between biventricular pacing (BVP) and left bundle branch area pacing (LBBAP) in patients with left ventricular ejection fraction (LVEF) ≤50% undergoing cardiac resynchronization therapy. Between January 2018 and June 2023, 2,579 patients were enrolled across 18 centers. The primary composite outcome was defined as all-cause mortality or heart failure hospitalization. LBBAP demonstrated a shorter paced QRS duration and was associated with a lower risk of primary composite outcome and heart failure hospitalization. No significant difference was observed in all-cause mortality. Additionally, procedural complications were lower with LBBAP.
This episode was planned in collaboration with Heart Rhythm TV with mentorship from Dr. Daniel Alyesh and Dr. Mehak Dhande.
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About
Dr. Theofanie Mela completed her medical residency in 1995 (St. Elizabeth's Medical Center, Boston, MA), cardiology fellowship in 1998 (University of Massachusetts Medical Center, Worcester, MA) and cardiac electrophysiology fellowship in 1999 (Massachusetts General Hospital, Boston, MA).
Dr. Mela is currently an Associate Professor in Medicine, Harvard Medical School, Boston, MA. She is a Staff Cardiac Electrophysiologist and the Director of Pacemaker and ICD Clinic, Massachusetts General Hospital, Boston, MA.
Dr. Mela is the course director for the Boston Lead Management Symposium.
Visit Mass General Hospital to learn more about Dr. Theofanie Mela.
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