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BackTable / ENT / Podcast / Episode #145

Understanding Drug Repurposing in Head & Neck Cancer

with Dr. Nicole Schmitt

In this podcast, Dr. Gopi Shah invites Dr. Nicole Schmitt, an associate professor in the Department of Otolaryngology at Emory University to discuss drug repurposing for head and neck cancer.

Dr. Schmitt explains that drug repurposing involves using a drug developed for one purpose for an entirely different purpose. She highlights some of the main drugs being repurposed for head and neck cancer treatment, including statins and NSAIDs. For example, Dr. Schmitt shares how manipulating cholesterol levels can enhance antineoplastic T lymphocyte responses to increase survival and treatment tolerability. The surgeons then consider the therapeutic, safety, and financial benefits of repurposed drugs. Special attention is given to drug repurposing in HPV-positive cancer. Lastly, Dr. Schmitt describes the pleiotropic effect and how it applies to drug repurposing efforts.

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Understanding Drug Repurposing in Head & Neck Cancer with Dr. Nicole Schmitt on the BackTable ENT Podcast)
Ep 145 Understanding Drug Repurposing in Head & Neck Cancer with Dr. Nicole Schmitt
00:00 / 01:04

BackTable, LLC (Producer). (2023, November 30). Ep. 145 – Understanding Drug Repurposing in Head & Neck Cancer [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Nicole Schmitt discusses Understanding Drug Repurposing in Head & Neck Cancer on the BackTable 145 Podcast

Dr. Nicole Schmitt

Dr. Nicole Schmitt is an associate professor with the department of otolaryngology at Emory University in Atlanta, Georgia.

Dr. Ashley Agan discusses Understanding Drug Repurposing in Head & Neck Cancer on the BackTable 145 Podcast

Dr. Ashley Agan

Dr. Ashley Agan is a practicing ENT and assistant professor at UT Southwestern Medical Center in Dallas, TX.

Dr. Gopi Shah discusses Understanding Drug Repurposing in Head & Neck Cancer on the BackTable 145 Podcast

Dr. Gopi Shah

Dr. Gopi Shah is a practicing ENT at UT Southwestern Medical Center in Dallas, TX.

Show Notes

0:00 - Drug Repurposing and Cancer Treatment
08:40 - Statins and NSAIDs for Head and Neck Cancer
12:18 - Enhancing Tumor Control With Pre-Surgery Drugs
22:14 - Treatment of Pre-Malignant Lesions With Repurposed Drugs

Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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