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BackTable / ENT / Podcast / Episode #145
Understanding Drug Repurposing in Head & Neck Cancer
with Dr. Nicole Schmitt
In this podcast, Dr. Gopi Shah invites Dr. Nicole Schmitt, an associate professor in the Department of Otolaryngology at Emory University to discuss drug repurposing for head and neck cancer.
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BackTable, LLC (Producer). (2023, November 30). Ep. 145 – Understanding Drug Repurposing in Head & Neck Cancer [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Dr. Nicole Schmitt
Dr. Nicole Schmitt is an associate professor with the department of otolaryngology at Emory University in Atlanta, Georgia.
Dr. Ashley Agan
Dr. Ashley Agan is an otolaryngologist in Dallas, TX.
Dr. Gopi Shah
Dr. Gopi Shah is a pediatric otolaryngologist and the co-host of BackTable ENT.
Synopsis
Dr. Schmitt explains that drug repurposing involves using a drug developed for one purpose for an entirely different purpose. She highlights some of the main drugs being repurposed for head and neck cancer treatment, including statins and NSAIDs. For example, Dr. Schmitt shares how manipulating cholesterol levels can enhance antineoplastic T lymphocyte responses to increase survival and treatment tolerability. The surgeons then consider the therapeutic, safety, and financial benefits of repurposed drugs. Special attention is given to drug repurposing in HPV-positive cancer. Lastly, Dr. Schmitt describes the pleiotropic effect and how it applies to drug repurposing efforts.
Timestamps
0:00 - Drug Repurposing and Cancer Treatment
08:40 - Statins and NSAIDs for Head and Neck Cancer
12:18 - Enhancing Tumor Control With Pre-Surgery Drugs
22:14 - Treatment of Pre-Malignant Lesions With Repurposed Drugs
Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
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