Episode # 102 • 25 Jun 2026
Understanding PRP & Orthobiologics for Musculoskeletal Medicine
Are you truly understanding PRP and orthobiologics, or just following the latest trends in musculoskeletal medicine? In this episode of BackTable Bone and Sports, host Dr. Larry Balle and guest Dr. Jason Epstein explore the realities of platelet-rich plasma (PRP) and orthobiologics in non-operative musculoskeletal medicine. They highlight why successful outcomes start with honest patient counseling, clear definitions of the procedure, and addressing common misconceptions such as PRP being “stem cells.”
Timestamps
00:00 - Introduction
09:02 - Exploring the Patient Definition of PRP
14:31 - Addressing Inconsistenties in the Literature for PRP
20:01 - Avoiding Stem Cell Terminology
26:24 - Encouraging Shared Decision Making
41:46 - Patient Selection, Dosing, and Post-Treatment Expectations
54:34 - Talking Cost of Treatment
58:07 - Choosing the Right Tool and Blood Draw Technique
01:01:31 - Personal Experience with PRP
01:05:35 - Discussing FDA Regulations and Marketing Myths
01:13:18 - Closing Remarks
Resources
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More about this episode
The discussion covers the lack of standardization in PRP studies, reasons for variable patient responses, and how to guide patients through shared decision-making and realistic expectations. Drs. Balle and Epstein emphasize building trust, avoiding marketing hype, and discussing FDA regulations, legality, and off-label use. Practical advice includes tracking outcomes and cell counts, clarifying costs, and choosing the right kits and techniques to integrate PRP responsibly into practice.
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