Dr. Geoffrey Buckle
Medical Oncologist
1 Podcast on BackTable
Dr. Geoffrey Buckle is a GI medical oncologist at UCSF in San Francisco, California.
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Episode # 86 • 20 Oct 2026
Optimizing Treatment for Advanced HER2-Positive Upper GI Cancers
When a gastroesophageal tumor is positive for HER2, PD-L1, and claudin 18.2, which target should you treat first and how do you decide? On this episode of the BackTable GI Oncology Creator Weekend™, host Dr. Kate Baker interviews Dr. Geoffrey Buckle, a GI medical oncologist at UCSF, and Dr. Ronan Hsieh, a GI oncologist at Swedish Cancer Institute in Seattle, for a breakdown of therapy selection and management in advanced HER2-positive upper GI cancers. They start with a detailed case, covering biomarker workup, how to choose a first-line regimen without head-to-head data, and how to manage nutrition and palliative radiation when a patient presents with dysphagia and weight loss.
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