Dr. Siddharth Sheth
Oncologist
2 Podcasts on BackTable
Dr. Siddharth Sheth is a head and neck medical oncologist at UNC School of Medicine in Chapel Hill, North Carolina.
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Episode # 33 • 04 Nov 2025
Keynote-689: Implementation & Multidisciplinary Care for Immunotherapy in Head & Neck Cancer
When treating head and neck cancer, how can you tell the difference between true disease progression and pseudoprogression? In this episode of the BackTable Podcast, we discuss the practical implementation of the KEYNOTE-689 trial published in the New England Journal of Medicine, which demonstrated the benefit of adding neoadjuvant and adjuvant immunotherapy to standard head and neck cancer care. Our tumor board panel includes Dr. Mihir Patel, a head and neck surgeon from UNC Chapel Hill, Dr. Siddharth Sheth, a head and neck medical oncologist from UNC, Dr. Jennifer Johnson, a professor of medical oncology and otolaryngology at Sidney Kimmel Comprehensive Cancer Center, and Dr. Adam Luginbuhl, a head and neck surgical oncologist at Thomas Jefferson University.
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About
Dr. Siddharth Sheth is a board-certified medical oncologist and a tenure-track Assistant Professor of Medicine in the Division of Medical Oncology with a secondary appointment in the Department of Otolaryngology at the University of North Carolina (UNC) at Chapel Hill. Dr. Sheth's clinical expertise is in the treatment of head and neck cancers (HNC) and thyroid cancers. Hid research focuses on early phase clinical trials and evaluating promising biomarkers.
At UNC, Dr. Sheth is a member of their dynamic head and neck cancer research program. He lead multiple clinical trials, many which are evaluating novel combinations of immunotherapy and targeted therapies. To complement this work, Dr. Sheth has developed a keen interest in non-invasive biomarkers, specifically circulating tumor DNA (ctDNA). Supported by an ASCO/Conquer Cancer Foundation Young Investigator Award (YIA; 2019) and 2021 NIH Paul Calabresi K12 Career Development Award in Clinical Oncology, he is studying if ctDNA can be an effective tool to monitor for treatment response and disease recurrence.
Dr. Sheth greatly enjoys caring for his HNC and thyroid cancer patients. The multidisciplinary team at UNC is deeply committed to providing the best care and support for their patients. By designing and leading clinical trials and translational studies, Dr. Sheth hope to positively impact his patient’s disease outcomes and their quality of life.
Visit UNC Health to learn more about Dr. Siddharth Sheth.
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