BackTable / Tumor Board / Podcast / Episode #41

Advanced Pancreatic Cancer: Systemic Therapy Strategies

with Dr. Shubham Pant and Dr. Jonathan Mizrahi

Metastatic pancreatic cancer is no longer a ‘one size fits all’ diagnosis. In this episode of the BackTable Tumor Board Podcast, medical oncologist Dr. Jon Mizrahi and Dr. Shubham Pant, a professor of GI Medical Oncology at MD Anderson Cancer Center, discuss the evolving landscape of systemic therapy for advanced pancreatic cancer.

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Advanced Pancreatic Cancer: Systemic Therapy Strategies with Dr. Shubham Pant and Dr. Jonathan Mizrahi on the BackTable Tumor Board Podcast

Ep 41 Advanced Pancreatic Cancer: Systemic Therapy Strategies with Dr. Shubham Pant and Dr. Jonathan Mizrahi

00:00 / 01:04

BackTable, LLC (Producer). (2025, December 30). Ep. 41 – Advanced Pancreatic Cancer: Systemic Therapy Strategies [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Jonathan Mizrahi

Dr. Jonathan Mizrahi is a medical oncologist with Ochsner Health in New Orleans, Louisiana.

Dr. Shubham Pant

Dr. Shubham Pant is a professor with the Department of Gastrointestinal Medical Oncology and Investigational Cancer Therapeutics at the University of Texas MD Anderson Cancer Center in Houston, Texas.

Synopsis

The doctors cover the current options for first- and second-line chemotherapy treatments, the significance of molecular profiling and germline testing, and the emerging potential of targeting KRAS mutations. The discussion also highlights the importance of supportive and palliative care for patients, focusing on pain management, nutritional support, and the role of pancreatic enzymes. The conversation concludes with speculation on the future of pancreatic cancer treatment and the need for improved access to clinical trials.

Timestamps

00:00 - Introduction
02:32 - First-Line Therapy Options
10:31 - Second-Line Therapy Options
20:18 - Challenges in Pancreatic Cancer Immunotherapy
26:47 - Supportive Care and Quality of Life
35:57 - Disparities in Pancreatic Cancer Treatment
38:58 - Conclusion and Future Directions

Resources

Adagrasib Clinical Trial
https://www.clinicaltrials.gov/study/NCT05853575

The Materials available on BackTable are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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