Episode # 556 • 08 Jul 2025
Dosimetry University Part IV: Optimizing Radiation Segmentectomy
Radiation segmentectomy: who, when, how? Interventional oncologists Dr. Nima Kokabi, Dr. Tyler Sandow, and Dr. Kavi Krishnasamy continue their in-studio discussion on all things Y90 in Part 4 of Dosimetry University, focusing on specific applications of radiation segmentectomy.
Timestamps
00:00 - Introduction
01:07 - Ablative Y90 Curative Outcomes and Survival Rates
02:16 - Radiation Segmentectomy vs. Ablation
09:22 - Case Study: Metastatic Colorectal Cancer
18:06 - Tumor Distinction on Cone Beam CT
19:58 - Case Study: 77-Year-Old Female with Breast and Colorectal Cancer
21:09 - Challenges and Techniques in Selective Radiation Segmentectomy
24:28 - Avastin and Y90
28:16 - Case Study: 53-Year-Old Male with Metastatic Colorectal Cancer
29:40 - Radiation Lobectomy and Hypertrophy Strategies
32:37 - Approaches for Metastatic and HCC Patients
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More about this episode
This session kicks off with a discussion on the curative potential of Y90, comparing it to other curative modalities like resection. The doctors discuss the importance of achieving a complete pathological necrosis (CPN) with Y90 for better survival outcomes, especially in the context of liver transplantation. The conversation also covers personalized approaches for treating liver-dominant metastatic cancers using Y90, and strategic considerations when choosing between techniques like radiation lobectomy, thermal ablation, and chemoembolization.
The interventional oncologists explore the viability of radiation segmentectomy in treating small lesions and discuss data supporting its efficacy. Real-world clinical cases are examined to highlight the practical application of these therapies, their impact on overall survival, and the intricacies of dosimetry and patient selection.
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