Episode # 72 • 14 Jul 2026
Optimizing Liver-Directed Interventions for Neuroendocrine Tumors
What factors come into play when deciding whether to use liver-directed therapy or systemic therapies for neuroendocrine tumors? In this episode of the BackTable Tumor Board Podcast, Dr. Lingling Du, Dr. Chih-Yi Liao, and Dr. Abdul Khan discuss the structure of a multidisciplinary tumor board and how they approach decision-making for patients with neuroendocrine tumors. The conversation explores who benefits most from liver-directed therapy, optimal timing for intervention, and the importance of individualized treatment planning.
Timestamps
00:00 - Introduction
02:04 - How The NET Tumor Board Works at UChicago
04:15 - Patients Who Benefits From Liver-Directed Therapy
10:45 - Non-candidates for Liver-Directed Therapy
13:37 - Choosing Modalities of Therapy: Bland TACE, Y90 and Ablation
15:16 - RETNET Trial Takeaways
21:38 - Histotripsy for Neuroendocrine Tumors
25:42 - Sequencing Liver-Directed Therapy With Systemic Therapy or PRRT
28:11 - Case One: Heavy Liver Burden
33:12 - Case Two: Aggressive NEC & Miracle Response
38:23 - Wrap Up and Credits
Resources
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More about this episode
The doctors review contraindications, modality selection, and sequencing with systemic therapy and PRRT before breaking down the RETNET trial, which shows similar hepatic progression-free survival between bland embolization and conventional TACE. They then discuss two patient cases, highlighting upfront embolization for heavy low-grade liver burden and repeat Y90 for oligometastatic high-grade neuroendocrine carcinoma with durable control.
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