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BackTable / Urology / Podcast / Episode #107

Use of Genomics for Active Surveillance

with Dr. Ashley Ross

In this episode of BackTable Urology, Dr. Aditya Bagrodia speaks with urological oncologist Dr. Ashley Ross from Northwestern University about risk factors of prostate cancer and the importance of genome expression tests to predict tumor characteristics.

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Use of Genomics for Active Surveillance with Dr. Ashley Ross on the BackTable Urology Podcast)
Ep 107 Use of Genomics for Active Surveillance with Dr. Ashley Ross
00:00 / 01:04

BackTable, LLC (Producer). (2023, July 19). Ep. 107 – Use of Genomics for Active Surveillance [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Ashley Ross discusses Use of Genomics for Active Surveillance on the BackTable 107 Podcast

Dr. Ashley Ross

Dr. Ashley Ross is an associate professor of urology and clinical director of the Polsky Urological Oncology Center at Northwestern Feinberg School of Medicine.

Dr. Aditya Bagrodia discusses Use of Genomics for Active Surveillance on the BackTable 107 Podcast

Dr. Aditya Bagrodia

Dr. Aditya Bagrodia is an associate professor of urology and genitourinary oncology team leader at UC San Diego Health in California and adjunct professor of urology at UT Southwestern.

Synopsis

First, the doctors summarize how to determine stage and risk of prostate cancer by assessing local and regional staging with MRI and PET-PSMA scans. They discuss the significant role of Gleason grade groups and genetic variants and genetic predisposition for prostate cancer. They underscore the importance of evaluation beyond the microscopic cellular structure of the cancer and using tools like MRI to reduce unnecessary biopsies.

Next, they explain the factors involved in the decision to treat or observe prostate cancer. Dr. Ross shares insights into the three possible lines of progression that prostate cancer can take and how to identify them in a patient. He illuminates the differences between germline and genomic testing, the impact of genomics on treatment decisions, and the crucial role of shared decision making. The doctors also consider the cost of genomics and the patient's expectation of what will happen before making a decision. Although there is a lack of standardization in the qualification and execution of prostate cancer surveillance, national trials are being done nationally that could influence guidelines around the use of genomics and active surveillance.

Resources

Decipher Prostate Genomic Classifier by Veracyte
https://www.veracyte.com/diagnostics/prostate-cancer

Transcript Preview

[Dr. Aditya Bagrodia]
It's my pleasure, Ashley. When I was thinking about the somewhat specific talk regarding bringing in next-generation molecular classifiers into our active surveillance algorithms, you're literally the first person that came to mind. You've done a tremendous amount of work in this field. I think you understand it both practically and analytically, and I really look forward to picking your brain on it.

[Dr. Ashley Ross]
That's very generous of you. I'm hoping that I can live up to those standards, but I'm sure we're going to have a good discussion.

Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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Articles

The Modern Role of Genomics & Imaging in Prostate Cancer Diagnosis & Treatment

The Modern Role of Genomics & Imaging in Prostate Cancer Diagnosis & Treatment

Active Surveillance for Prostate Cancer: A Tailored Approach

Active Surveillance for Prostate Cancer: A Tailored Approach

Topics

Prostate Cancer Condition Overview
Learn about Urologic Oncology on BackTable Urology

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