BackTable / Urology / Podcast / Episode #267

Sequencing Therapies in NMIBC Management

with Dr. Mark Tyson and Dr. Suzanne Merrill

New FDA-approved therapies for BCG-refractory non-muscle invasive bladder cancer (NMIBC)–where do they fit in the treatment algorithm, and how do you administer them? This installment of the 2025 NMIBC Creator Weekend™ series features host Dr. Bogdana Schmidt, assistant professor of Urologic Oncology at the University of Utah, and leading urologic oncologists Dr. Mark Tyson from Mayo Clinic Arizona and Dr. Suzanne Merrill from Colorado Urology.

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Sequencing Therapies in NMIBC Management with Dr. Mark Tyson and Dr. Suzanne Merrill on the BackTable Urology Podcast

Ep 267 Sequencing Therapies in NMIBC Management with Dr. Mark Tyson and Dr. Suzanne Merrill

00:00 / 01:04

BackTable, LLC (Producer). (2025, October 21). Ep. 267 – Sequencing Therapies in NMIBC Management [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Suzanne Merrill

Dr. Suzanne Merrill is a urologic oncologist with Colorado Urology in Denver, Colorado.

Dr. Bogdana Schmidt

Dr. Bogdana Schmidt, MD, MPH, is a urologic surgeon specializing in urologic oncology at the University of Utah in Salt Lake City, Utah.

Dr. Mark Tyson

Dr. Mark Tyson is a urologic oncologist and professor of urology with Mayo Clinic in Scottsdale, Arizona.

Synopsis

The discussion delves into the newest treatment strategies and FDA-approved therapies for non-muscle invasive bladder cancer with an emphasis on BCG-refractory patients. They highlight their approaches to sequencing therapies, the real-world applicability of these treatments, and the impact of patient factors in clinical decision-making. The panel also explores emerging trials and innovative treatment mechanisms, emphasizing the importance of personalized care in oncology.

Timestamps

00:00 - Introduction
05:09 - Challenges and Strategies in Treatment
10:55 - Bladder Sparing Therapies
21:41 - Practical Tips for Therapy Administration
30:39 - Challenges and Considerations in Reinduction
37:05 - Clinical Trials and Future Directions
44:11 - Counseling Patients on Treatment Options
57:36 - Concluding Thoughts and Future Outlook

Resources

CORE-008 Clinical Trial
https://www.sciencedirect.com/science/article/abs/pii/S1078143924010147

Legend Clinical Trial:
https://ascopubs.org/doi/10.1200/JCO.2025.43.5_suppl.802

CISTO Study
https://pubmed.ncbi.nlm.nih.gov/37980511/

The Materials available on BackTable are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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Articles

Topics

Non-Muscle Invasive Bladder Cancer (NMIBC) Podcasts

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