Dr. Erika Hamilton
Medical Oncologist
1 Podcast on BackTable
Dr. Erika Hamilton is a medical oncologist practicing at Sarah Cannon Research Institute in Nashville, Tennessee.
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Episode # 48 • 17 Feb 2026
HER2-Positive Metastatic Breast Cancer: Treatment Insights & Protocols
In a patient with metastatic HER2-positive breast cancer, what should guide the next decision: trial data, toxicity, or durability of response? In this episode of BackTable Tumor Board, Dr. Lindsay Peterson (Washington University) sits down with Dr. Erica Hamilton (Sarah Cannon Research Institute) to examine how next-generation HER2-directed therapies are reshaping the management of metastatic disease. As treatment options expand beyond trastuzumab-based regimens to agents such as trastuzumab deruxtecan and tucatinib, clinical decision-making increasingly hinges on sequencing strategy, interpretation of evolving trial data, and thoughtful toxicity management.
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About
Erika Hamilton, M.D., is a board-certified medical oncologist and the Director of Breast Cancer and Gynecologic Cancer Research at Sarah Cannon Research Institute. She specializes in breast cancer and gynecologic cancer treatment and research. In her role, Dr. Hamilton oversees the research program and clinical trial menu for gynecologic and breast cancer from a medical oncology perspective.
Dr. Hamilton is a past chair of ASCO’s Scientific Breast Committee a ’21-’22, participant of the ASCO Leadership Development Program, Associate Editor for Clinical Breast Cancer, co-chair for Great Debates and Updates in Women’s Oncology Conference and a board member of the Susan G. Komen Foundation of Central Tennessee. She is a member of the European Society of Medical Oncology, American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO) and American Medical Association.
Dr. Hamilton serves as a reviewer for the medical journals Clinical Breast Cancer, New England Journal of Medicine, Oncology, American Journal of Hematology/Oncology and the Journal of Clinical Oncology. She has also spoken at numerous industry conferences and events. She is active in the community, volunteering with Gilda’s Club Middle Tennessee, the American Cancer Society’s Hope Lodge, Ovarcome ovarian cancer support organization, Brentwood Baptist Church and the Susan G. Komen Race for the Cure.
Dr. Hamilton earned her medical degree from Washington and Lee University. She then completed an internal medicine residency at the University of North Carolina at Chapel Hill, followed by a hematology/oncology fellowship at Duke University. During her fellowship, she was a Top 5 Finalist for Duke’s Annual House Staff Fellow Teaching Award. When she is not treating patients and conducting research, Dr. Hamilton enjoys spending time with her daughters, attending their sporting events, going to parks and nature hiking. She also has a deep appreciation for great food.
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