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BackTable / Urology / Podcast / Episode #256
The Role of ctDNA in Bladder Cancer Diagnosis & Treatment
with Dr. Alberto Pieretti
Could ctDNA testing allow us to treat bladder cancer earlier, smarter, and more effectively? In this episode of BackTable Urology, Dr. Alberto Pieretti, a urologic oncologist at Cleveland Clinic Weston Hospital, joins host Dr. Jose Silva to explore the emerging role of ctDNA in bladder cancer management.
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BackTable, LLC (Producer). (2025, August 22). Ep. 256 – The Role of ctDNA in Bladder Cancer Diagnosis & Treatment [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Dr. Alberto Pieretti
Dr. Alberto Pieretti is a urologic oncologist at Cleveland Clinic Weston Hospital in Parkland, Florida.
Dr. Jose Silva
Dr. Jose Silva is a board certified urologist practicing in Central Florida.
Synopsis
Dr. Pieretti and Dr. Silva discuss how ctDNA can refine staging, identify patients at risk of recurrence, and guide decisions on when to intensify treatment. The conversation also examines its potential to detect actionable mutations, inform precision therapies, and shape the design of future clinical trials in urologic oncology.
Timestamps
0:00 - Introduction
2:50 - Overview of Bladder Cancer
12:59 - Overview of ctDNA
20:34 - Current ctDNA Trials
27:21 - Clinical Implications of ctDNA
31:20 - Conclusion
Resources
Updated Overall Survival by Circulating Tumor DNA Status from the Phase 3 IMvigor010 Trial: Adjuvant Atezolizumab Versus Observation in Muscle-invasive Urothelial Carcinoma - PubMed
https://pubmed.ncbi.nlm.nih.gov/37500339/
Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer | New England Journal of Medicine
https://www.nejm.org/doi/abs/10.1056/NEJMoa2408154
Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
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