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BackTable / OBGYN / Podcast / Episode #58
Understanding Rising Endometrial Cancer Rates
with Dr. Amanda Fader and Dr. Matthew Powell
Gynecologic oncology experts Dr. Matthew Powell from Washington University School of Medicine and Dr. Amanda Fader from Johns Hopkins Hospital discuss the increasing rates of endometrial cancer along with future directions of treatments and screenings.
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BackTable, LLC (Producer). (2024, June 25). Ep. 58 – Understanding Rising Endometrial Cancer Rates [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Dr. Amanda Fader
Dr. Amanda Fader is a professor of gynecology, obstetrics and oncology and a gynecologic oncologist with Johns Hopkins Medicine in Baltimore, Maryland.
Dr. Matthew Powell
Dr. Matthew Powell is a professor of obstetrics and gynecology and a gynecologic oncologist with Washington University in St. Louis, Missouri.
Dr. Amy Park
Dr. Amy Park is the Section Head of Female Pelvic Medicine & Reconstructive Surgery at the Cleveland Clinic, and a co-host of the BackTable OBGYN Podcast.
Synopsis
First, the physicians discuss trends in endometrial cancer rates and delve into the factors driving these trends, such as the obesity epidemic and aging population. They explore the differences between endometrioid and non-endometrioid cancers, along with the impact of racial and geographic disparities. The conversation also covers advances in diagnostics and treatments—including immunotherapy and targeted therapies—and the critical need for better awareness, screening practices, and research funding to combat this public health threat.
Timestamps
00:00 - Introduction
03:11 - Types of Endometrial Cancer
04:44 - Rising Rates and Risk Factors
08:03 - Disparities in Endometrial Cancer Care
10:37 - Symptoms and Diagnosis
13:52 - Ultrasound vs. Biopsy
16:17 - Challenges in Biopsies
20:58 - Management/Treatment Approaches
23:03 - Geographic Disparities/Access to Care
26:07 - Vaginal Brachytherapy
32:11 - Innovations in Treatment and Research
40:34 - Future Directions: Endometrial Screening
43:54 - AI in Gynecologic Oncology
Resources
Beavis, A. L., Blechter, B., Najjar, O., Fader, A. N., Katebi Kashi, P., & Rositch, A. F. (2023). Identifying women 45 years and younger at elevated risk for endometrial hyperplasia or cancer. Gynecologic Oncology, 174, 98–105. https://doi.org/10.1016/j.ygyno.2023.04.019
Mirza, M. R., Sharma, S., Roed, H., Landrum, L. M., Gilbert, L., Gold, M. A., Novák, Z., Edelson, M., Meirovitz, M., Diaz, J. P., Huygh, G., Buscema, J., Pothuri, B., Eshed, H. D., Coleman, R. L., Slomovitz, B. M., Kostadinov, R., Stevens, S., Ronzino, G., & Powell, M. A. (2024). Post hoc analysis of progression-free survival (PFS) and overall survival (OS) by mechanism of mismatch repair (MMR) protein loss in patients with endometrial cancer (EC) treated with Dostarlimab plus chemotherapy in the ruby trial. Journal of Clinical Oncology, 42(16_suppl), 5606–5606. https://doi.org/10.1200/jco.2024.42.16_suppl.5606
Society of Gynecologic Oncology (SGO):
https://www.sgo.org/
Transcript Preview
[Dr. Amanda Fader]
Endometrial cancer is the fourth most common cause of cancer in women in the U.S. But, given some of these trends that Matt is talking about, we are set in 2030 to see endometrial cancer overcome colon cancer to become the third leading cause of cancer in women. So these are really, really disturbing both incidence and mortality trends, and when you look at all cancers together, while most solid tumors in the world are decreasing in incidence or plateauing in incidence, endometrial cancer is one of the only cancers that's rising in both incidence and mortality for many of the reasons that Matt described. And so this is a real call to action here and a huge public health threat for women.
Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
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