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Hypertension
Systolic blood pressure greater than 160 mmHg.
Renal disease
Includes dialysis, kidney transplant, or serum creatinine greater than 2.26 mg/dL (200 µmol/L).
Liver disease
Defined as cirrhosis or biochemical evidence such as bilirubin over 2 times normal with AST, ALT, or alkaline phosphatase over 3 times normal.
Stroke
History of ischemic or hemorrhagic stroke.
Bleeding
Prior major bleeding or known bleeding predisposition.
Labile INR
Unstable or high INRs with time in therapeutic range below 60%.
Elderly
Age over 65 years.
Drugs
Use of medications that increase bleeding risk, such as aspirin, clopidogrel, or NSAIDs.
Alcohol
Consumption of 8 or more alcoholic drinks per week.
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