BackTable / ENT / Podcast / Episode #19

Immunotherapy for Head and Neck Cancer

with Dr. Adam Luginbuhl

Dr. Adam Luginbuhl from Thomas Jefferson University Hospitals gives us the 101 on Immunotherapy as a treatment option for Head and Neck Cancer.

Sponsored by:

Edward Jones
Immunotherapy for Head and Neck Cancer with Dr. Adam Luginbuhl on the BackTable ENT Podcast)
Ep 19 Immunotherapy for Head and Neck Cancer with Dr. Adam Luginbuhl
00:00 / 01:04

BackTable, LLC (Producer). (2021, March 30). Ep. 19 – Immunotherapy for Head and Neck Cancer [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Adam Luginbuhl discusses Immunotherapy for Head and Neck Cancer on the BackTable 19 Podcast

Dr. Adam Luginbuhl

Dr. Adam Luginbuhl is an Associate Professor of Otolaryngology Head and Neck Surgery at Thomas Jefferson University.

Dr. Gopi Shah discusses Immunotherapy for Head and Neck Cancer on the BackTable 19 Podcast

Dr. Gopi Shah

Dr. Gopi Shah is a practicing ENT at UT Southwestern Medical Center in Dallas, TX.

Dr. Ashley Agan discusses Immunotherapy for Head and Neck Cancer on the BackTable 19 Podcast

Dr. Ashley Agan

Dr. Ashley Agan is a practicing ENT and assistant professor at UT Southwestern Medical Center in Dallas, TX.

Show Notes

In this episode, Dr. Adam Luginbuhl joins Dr. Gopi Shah and Dr. Ashley Agan to discuss immunotherapy for treatment of head and neck cancer.

Dr. Luginbuhl describes the basics of cancer immunotherapy which aims to harness the body’s intrinsic immune system to target cancer cells. He provides an overview of the main checkpoint inhibitors (CTLA-4, PD-1, PDL-1) and their mechanisms of action. He also highlights new research developments aimed at exploring the role of immunotherapy as a neoadjuvant prior to surgery.

He then discusses the challenges in recruiting for clinical trials whereby he must find the balance between offering promising new treatments with limited evidence and traditional therapies. He states that the main contraindication and side-effect of immunotherapy is auto-immunity.

He emphasizes that the journey with head and neck cancer does not end after treatment. Since the head and neck region is vital to our interactions with the world – our appearance, our voice, our ability to eat and drink – he states that treatment should not only be focused on clearing cancer, but also maintaining patient quality-of-life.

Resources

Review Articles: Immunotherapy for Head and Neck Cancer:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586169/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749717/

National Cancer Databases:

National Comprehensive Cancer Network: https://www.nccn.org
American Head and Neck Society: https://www.ahns.info
National Cancer Institute: https://www.cancer.gov

Transcript Preview

[Dr. Gopi Shah]
When you talk to patients about the checkpoint inhibitors and the drugs that are available, does it help them in terms of survival/cure, or does it buy them more time? Are you talking about months or years? talking years? Is it more symptom relief or palliation?

[Dr. Adam Luginbuhl]
For those listeners who see patients on a regular basis, or those who have a family member with cancer, this might help in some way. One of the beautiful things about this is most replicated and probably first produced in melanoma, and we're seeing the same thing in head and neck. It's this thing called the “long tail.”

Let's talk about chemotherapy first, as a baseline. You give someone chemotherapy A and then you give another patient chemotherapy B. And what we saw with chemotherapy, is that it maybe extended life for 6 or 10 months, but ultimately everybody in the group of really sick patients did not survive. We're not talking about curable people, we're talking about really sick ones.

With immunotherapy, we see a different curve. We see that curve where you not only have 6 or 7 months of progression-free survival and improvement, but you also have this long tail in about 15% to 20% of patients that just survive. We have beautiful pictures of these initial PET scans in people with melanoma everywhere-- bones, lungs, everywhere. And then the next PET scan, nothing. And they go on for 5, 10, 15, 20 years. That's revolutionary. That's new. That's a different expectation.

Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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Articles

Topics

Head and Neck Cancer Condition Overview
Immunotherapy Procedure Prep

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