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BackTable / Urology / Podcast / Episode #126

Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance

with Dr. Rana McKay and Dr. Shankar Siva

This week on BackTable Urology, Dr. Aditya Bagrodia (UCSD), medical oncologist Dr. Rana McKay (UCSD) and radiation oncologist Dr. Shankar Siva (University of Melbourne) discuss the growing role of radiation therapy in kidney cancer treatment.

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Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance with Dr. Rana McKay and Dr. Shankar Siva on the BackTable Urology Podcast)
Ep 126 Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance with Dr. Rana McKay and Dr. Shankar Siva
00:00 / 01:04

BackTable, LLC (Producer). (2023, October 11). Ep. 126 – Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Rana McKay discusses Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance on the BackTable 126 Podcast

Dr. Rana McKay

Dr. Rana McKay is a medical oncologist and associate professor at UC San Diego Health in California.

Dr. Shankar Siva discusses Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance on the BackTable 126 Podcast

Dr. Shankar Siva

Dr. Shankar Siva is a professor of radiation oncology at Peter MacCallum Cancer Centre at the University of Melbourne in Australia.

Dr. Aditya Bagrodia discusses Radiation’s Evolving Role in Kidney Cancer: From Resistance to Relevance on the BackTable 126 Podcast

Dr. Aditya Bagrodia

Dr. Aditya Bagrodia is an associate professor of urology and genitourinary oncology team leader at UC San Diego Health in California and adjunct professor of urology at UT Southwestern.

Synopsis

Shankar first explains the original historical studies that provided evidence of the limited efficacy of low dose conventional radiation therapy (RT) in treating kidney cancer. However, he and Rana discuss how stereotactic body radiation therapy (SBRT), a newer technology which delivers a higher dose per fraction more accurately, has shown better outcomes in clinical trials than conventional RT. They also explain the associated risks with SBRT and how neoadjuvant therapies can be combined with radiation. They also consider the use of SBRT in bulky tumors and those with IVC thrombus. All three doctors agree that radiation therapy needs to be incorporated into a multimodal approach to kidney cancer. They also discuss the potential of radiation therapy in the cytoreductive setting and its role in delaying systemic therapy in patients with oligometastases.

Finally, they explore the possibility of using PET imaging to detect oligometastatic disease. Although prostate-specific membrane antigen positron emission tomography (PSMA PET/CT) imaging is mostly used to stage prostate cancer, other solid tumors like renal cell carcinoma (RCC) may also express PSMA. For this reason, they agree that a next generation PSMA PET/CT equivalent for RCC could be revolutionary. Lastly, they predict what the future of RCC could hold by examining newer therapies, such as radioligand therapy and cyberknife.

Resources

Kidney Cancer Association: 2023 International Kidney Cancer Symposium (Nov. 9-11)
https://www.kidneycancer.org/ikcs/2023-ikcs-north-america/

Decipher by Veracyte
https://decipherbio.com/

WellPrept
https://wellprept.com/

Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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Topics

Kidney Cancer Condition Overview
Radiation Therapy Procedure Prep
Learn about Urologic Oncology on BackTable Urology

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